Traverso and colleagues based the L-SOMA on their initial invention, the SOMA, which injects solid medications but does not work with liquid drugs. After the L-SOMA delivers the drug, the needle retracts back into the capsule. The pill contains a retractable needle that injects the treatment directly into tissue within the stomach. The researchers designed the L-SOMA so that it can be loaded with up to 4 mg doses of a desired medication. "Our group focuses on developing systems that make it easier for patients to receive their medications." Giovanni Traverso, MB, BChir, PhD, of the Division of Gastroenterology, Hepatology and Endoscopy at the Brigham and the Department of Mechanical Engineering at MIT. If we can make it easier for patients to receive their medication, we can help maximize drug adherence or compliance," said C. "We recognize today that pills are the preferred route of drug administration, not only for patients, but also for health care providers. Findings are published in Nature Biotechnology.
In large animal preclinical models, investigators used this technology to deliver four commonly injected medications, including a monoclonal antibody. But what if you could take monoclonal antibodies, insulin and other injectables as a pill? A study by investigators at Brigham and Women's Hospital, Massachusetts Institute of Technology and Novo Nordisk unveils a new type of self-injecting capsule, called the liquid-injecting self-orienting millimeter-scale applicator (L-SOMA) that administers typically injected liquid medications orally. These injections require training, equipment and often take a toll on one's life. Many people suffering from diseases like Crohn’s disease, rheumatoid arthritis, and diabetes inject themselves or have to receive drug infusions to help treat their disease.
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